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Neurotoxins: Free Radical Mechanisms and Melatonin Protection against Molecular Mutilation
In this survey we summarize the publications related to the following neurotoxins and the protective actions of melatonin:
aminolevulinic
acid
, cyanide, domoic acid, kainic acid, metals, methamphetamine, polychlorinated biphenyls, rotenone, toluene and 6-hydroxydopamine."
In this survey we summarize the publications related to the following neurotoxins and the protective actions of melatonin:
aminolevulinic
acid
, cyanide, domoic acid, kainic acid, metals, methamphetamine, polychlorinated biphenyls, rotenone, toluene and 6-hydroxydopamine."
SilentEchoes
in
Cure Parkinson's
1 year ago
Hot flushes
Hello I’m on week 4 of daily pred (20mg), 30mg lanzaprozole, 70mg alendronic acid (weekly not daily). I’ve suddenly started having horrendous hot flushes - mainly at night but yesterday evening had a horrible sweaty and ill feeling 30 mins. Very reminiscent of my early menopause days pre HRT. I have
Hello I’m on week 4 of daily pred (20mg), 30mg lanzaprozole, 70mg alendronic acid (weekly not daily). I’ve suddenly started having horrendous hot flushes - mainly at night but yesterday evening had a horrible sweaty and ill feeling 30 mins. Very reminiscent of my early menopause days pre HRT. I have
NewPMR53
in
PMRGCAuk
1 day ago
Neuropathy fatty liver
Hi, I have fatty liver with minimal scarring. For last 6 years both my big toes have been numb from neuropathy. Recently I have started getting numbness in my thumbs and thighs. Has anyone else had such problems and what to do about it? My Dr prescribed 300mg gabapentin 2 times a day but doesn't really
Hi, I have fatty liver with minimal scarring. For last 6 years both my big toes have been numb from neuropathy. Recently I have started getting numbness in my thumbs and thighs. Has anyone else had such problems and what to do about it? My Dr prescribed 300mg gabapentin 2 times a day but doesn't really
glander2405
in
British Liver Trust
2 days ago
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How is PMR diagnosed?
At the end of January after starting on a weekly alendronate, I began having stiffness in legs and shoulder / arm pain. I couldn't get up from an arm chair and sleeping was disrupted by pain and trips to the bathroom because I was taking various pain meds. My doctor thought it was arthritis but did
At the end of January after starting on a weekly alendronate, I began having stiffness in legs and shoulder / arm pain. I couldn't get up from an arm chair and sleeping was disrupted by pain and trips to the bathroom because I was taking various pain meds. My doctor thought it was arthritis but did
JubileePenny
in
PMRGCAuk
2 days ago
Blood Tests to show if Calcium is being absorbed into the bones and not elsewhere....
Does anyone know if there's blood test than can tell if the calcium supplements are in fact going to the right place ( the bones) and not being absorbed into the bloodstream, if so what's it called? I have been diagnosed, via the DEXA scan, with severe osteoporosis, but I don't understand the explanation
Does anyone know if there's blood test than can tell if the calcium supplements are in fact going to the right place ( the bones) and not being absorbed into the bloodstream, if so what's it called? I have been diagnosed, via the DEXA scan, with severe osteoporosis, but I don't understand the explanation
Cheerleader123
in
Bone Health and Osteoporosis UK
3 days ago
Estrogen for Bone Health in PCa patient.
I am under treatment for Prostrate Cancer since mid 2019. Gleason 9-10 when detected with 250 PSA. Pet CT showed all contained in prostrate but with one ECE and seminal vesicles involvement. No spread visible to lymph nodes or anywhere in the body. Treatment was conventional ADT using Firmagon for 4
I am under treatment for Prostrate Cancer since mid 2019. Gleason 9-10 when detected with 250 PSA. Pet CT showed all contained in prostrate but with one ECE and seminal vesicles involvement. No spread visible to lymph nodes or anywhere in the body. Treatment was conventional ADT using Firmagon for 4
binati
in
Advanced Prostate Cancer
4 days ago
Persistent UTI's, appears only with sexual activity without protection
History of urinary tract infection I have had this infection for 3 years, Escherichia coli always comes out in the urine culture, except for one time when Proteus came out. For treatment I have used ciprofloxacin, amikacin, nitrofurantoin, levofloxacin (but there was resistance to it), Amoxicillin
History of urinary tract infection I have had this infection for 3 years, Escherichia coli always comes out in the urine culture, except for one time when Proteus came out. For treatment I have used ciprofloxacin, amikacin, nitrofurantoin, levofloxacin (but there was resistance to it), Amoxicillin
tere126
in
Women's Health
5 days ago
Ursodeoxycholic acid (UDCA) and tauroursodeoxycholic acid (TUDCA)
The paper below is the most detailed and well referenced I have read regarding UDCA and TUDCA. Incredibly thorough. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258966/#CR128
The paper below is the most detailed and well referenced I have read regarding UDCA and TUDCA. Incredibly thorough. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258966/#CR128
JDRhope
in
Cure Parkinson's
7 days ago
Please share any experience of meds to try and prevent osteoporosis especially Zoledronic acid and Romosozumab
I've recently had spinal or vertebral compression fractures and am now talking to various health care professionals and researching my options to try and prevent further fractures in the future. Because the risk is so high given my age (young at 63 but post-menopause) and long-term steroids I may
I've recently had spinal or vertebral compression fractures and am now talking to various health care professionals and researching my options to try and prevent further fractures in the future. Because the risk is so high given my age (young at 63 but post-menopause) and long-term steroids I may
tangocharlie
in
PMRGCAuk
9 days ago
When to take meds
I have been on levothyroxine 75mg for few years now I have to take alendronic acid and adcal d3 for my bones. I now read you should not take aa and levo at same time been prescribed to take in morn. The adcal d3 at night wondered if anyone on same how they take them. Has anyone got side effects from
I have been on levothyroxine 75mg for few years now I have to take alendronic acid and adcal d3 for my bones. I now read you should not take aa and levo at same time been prescribed to take in morn. The adcal d3 at night wondered if anyone on same how they take them. Has anyone got side effects from
bellsjet
in
Thyroid UK
11 days ago
Alendronic Acid
Hi I have been getting heartburn after taking Alendronic Acid recently. Am on weekly dose. Have been taking for 3 months. My Dexa scan came back normal and the Rheumy says to stay on until Prednisolone stops which would be at least next March. I want to stop now as would rather risk fractures
Hi I have been getting heartburn after taking Alendronic Acid recently. Am on weekly dose. Have been taking for 3 months. My Dexa scan came back normal and the Rheumy says to stay on until Prednisolone stops which would be at least next March. I want to stop now as would rather risk fractures
Havanahula
in
PMRGCAuk
12 days ago
Nycii
Anyone have experience of Alendronic acid .? Good or bad please ?
Anyone have experience of Alendronic acid .? Good or bad please ?
Nyci
in
PMRGCAuk
12 days ago
Important from The PBC Foundation....
We are asking for your help. 4/6/2024 Very directly. Very succinctly. We need your help. This is the most important thing the Foundation has ever worked on: more important than the surveys, more important than the helpline, more important than the name change. We are writing a letter which we
We are asking for your help. 4/6/2024 Very directly. Very succinctly. We need your help. This is the most important thing the Foundation has ever worked on: more important than the surveys, more important than the helpline, more important than the name change. We are writing a letter which we
DonnaBoll
Administrator
in
PBC Foundation
14 days ago
Advice on P1NP test please....
I was diagnosed with osteoporosis of the spine 2 years ago and have (after lots of deliberation) agreed I should start taking alendronic acid. I also have hypothyroidism and when I saw my endocronologist (who happens to also be a osteoporosis specialist) he said I should get a P1NP marker test done before
I was diagnosed with osteoporosis of the spine 2 years ago and have (after lots of deliberation) agreed I should start taking alendronic acid. I also have hypothyroidism and when I saw my endocronologist (who happens to also be a osteoporosis specialist) he said I should get a P1NP marker test done before
Zadock
in
Bone Health and Osteoporosis UK
24 days ago
kyphosis
I was diagnosed with OP about 10 years ago due to an early menopause at 38 and was put on the weekly medication of Alendronic Acid along with calcichew. Everything was ok until 2021 when I had emergency abdominal surgery, I was in ICU for nine days and my family were told I only had a 30% chance of
I was diagnosed with OP about 10 years ago due to an early menopause at 38 and was put on the weekly medication of Alendronic Acid along with calcichew. Everything was ok until 2021 when I had emergency abdominal surgery, I was in ICU for nine days and my family were told I only had a 30% chance of
Kimm4
in
Bone Health and Osteoporosis UK
25 days ago
When PMR Goes Away
When first diagnosed with PMR and feeling like I was never going to be myself again, some friends, acquaintances and even a couple medical professionals assured me the diagnosis was the best of the myalgia’s to have to deal with because it is the one that actually goes away. If you do some research,
When first diagnosed with PMR and feeling like I was never going to be myself again, some friends, acquaintances and even a couple medical professionals assured me the diagnosis was the best of the myalgia’s to have to deal with because it is the one that actually goes away. If you do some research,
fondofforest
in
PMRGCAuk
25 days ago
what is the risk from ALA?
What is this community’s take on ALA, as found in flaxseed oil? Is there risk for prostate cancer? If there is “risk”, is that solely an association with increased PSA? i.e. do significant amounts of flaxseed oil cause a change only in one’s baseline PSA? i.e. does it promote the [i]
production[
What is this community’s take on ALA, as found in flaxseed oil? Is there risk for prostate cancer? If there is “risk”, is that solely an association with increased PSA? i.e. do significant amounts of flaxseed oil cause a change only in one’s baseline PSA? i.e. does it promote the [i]
production[
lokibear0803
in
Advanced Prostate Cancer
27 days ago
weird raised big veins in feet and legs both
has anyone else had weird raised veins in legs and feet ?? i went to gp yesterday saw yet a different doctor she hadn’t read any of my notes before arrival and it was after a phone call where I mentioned my veins they called me in to take a look- she made me go through telling her my history when I
has anyone else had weird raised veins in legs and feet ?? i went to gp yesterday saw yet a different doctor she hadn’t read any of my notes before arrival and it was after a phone call where I mentioned my veins they called me in to take a look- she made me go through telling her my history when I
Pol53
in
PMRGCAuk
27 days ago
Two updates in the Guidelines for PBC
PRACTICE GUIDANCE Primary biliary cholangitis: 2021 practice guidance update from the American Association for the Study of Liver Diseases Lindor, Keith D.*,1; Bowlus, Christopher L.2; Boyer, James3; Levy, Cynthia4; Mayo, Marlyn5 Author Information Hepatology 75(4):p 1012-1013, April 2022. | DOI
PRACTICE GUIDANCE Primary biliary cholangitis: 2021 practice guidance update from the American Association for the Study of Liver Diseases Lindor, Keith D.*,1; Bowlus, Christopher L.2; Boyer, James3; Levy, Cynthia4; Mayo, Marlyn5 Author Information Hepatology 75(4):p 1012-1013, April 2022. | DOI
DonnaBoll
Administrator
in
PBC Foundation
28 days ago
One piece at a time.....
Over the next week or so, I'd like to familiarize you with the guidelines officially established regarding PBC. I will post of a section of the Guidelines. Any discussion or comments would be welcomed. The next guidelines we will talk about are the EASL Guidelines -the European Association for the
Over the next week or so, I'd like to familiarize you with the guidelines officially established regarding PBC. I will post of a section of the Guidelines. Any discussion or comments would be welcomed. The next guidelines we will talk about are the EASL Guidelines -the European Association for the
DonnaBoll
Administrator
in
PBC Foundation
29 days ago
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