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JAK2 V617F Allele Burden and Thrombotic Events in Patients w/ JAK2 V617F Positive PCV/ET @ High Risk of Thrombosis
The cumulative incidence of
thrombosis
at 7 years was 35.5%.
Arterial
thrombosis
(93.8%) predominated. Median overall survival was 103.6 months (95% CI 68.8–138.4). Median thrombosis-free survival was 86 months (95% CI 68.4–103.6).
The cumulative incidence of
thrombosis
at 7 years was 35.5%.
Arterial
thrombosis
(93.8%) predominated. Median overall survival was 103.6 months (95% CI 68.8–138.4). Median thrombosis-free survival was 86 months (95% CI 68.4–103.6).
PhysAssist
in
MPN Voice
2 months ago
Polycythemia vera: 2024 update on diagnosis, risk-stratification, and management
Additional predictors for
arterial
thrombosis
include cardiovascular risk factors and for venous thrombosis higher absolute neutrophil count and JAK2V617F allele burden. Treatment Current goal of therapy is to prevent thrombosis.
Additional predictors for
arterial
thrombosis
include cardiovascular risk factors and for venous thrombosis higher absolute neutrophil count and JAK2V617F allele burden. Treatment Current goal of therapy is to prevent thrombosis.
Manouche
in
MPN Voice
1 year ago
Weird leg pain
Hi everyone, I'm hoping someone can shed some light on this weird symptom! For almost 10 years now I have had pain in my outer calf about two inches up from my ankle on both sides. It comes on with the slightest exertion but is not there all the time. The achy pain builds and builds until I feel like
Hi everyone, I'm hoping someone can shed some light on this weird symptom! For almost 10 years now I have had pain in my outer calf about two inches up from my ankle on both sides. It comes on with the slightest exertion but is not there all the time. The achy pain builds and builds until I feel like
Womble84
in
Endometriosis UK
22 days ago
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How long for platelets to go back up?
Hello Since the start of my husband's cirrhosis journey last August, with a variceal bleed, his platelets went as low as 2700. Since then they rose to 6000 at one point and are now back down to 5000. I thought they would have gone much more by now but he is also on blood thinners because he has portal
Hello Since the start of my husband's cirrhosis journey last August, with a variceal bleed, his platelets went as low as 2700. Since then they rose to 6000 at one point and are now back down to 5000. I thought they would have gone much more by now but he is also on blood thinners because he has portal
looby24
in
British Liver Trust
4 months ago
Immunoglobulin tests
Hi again. Yesterday I asked my GP if I could have my blood immunoglobulin levels checked as I like to keep a handle on those parameters which can indicate the status of my immune system. To be honest, I thought this would be done without question and routinely. However, my doc prefers that my CLL haematologist
Hi again. Yesterday I asked my GP if I could have my blood immunoglobulin levels checked as I like to keep a handle on those parameters which can indicate the status of my immune system. To be honest, I thought this would be done without question and routinely. However, my doc prefers that my CLL haematologist
Fogey
in
CLL Support
4 months ago
difference between portal vein thrombosis and portal hypertension?
Good evening. New here. Husband in hospital with liver cirrhosis. Having scope on Monday and we were told today that he has portal vein thrombosis. I understand what that is but I’m confused after doing some research as to the difference between portal vein thrombosis and portal vein hypertension? Or
Good evening. New here. Husband in hospital with liver cirrhosis. Having scope on Monday and we were told today that he has portal vein thrombosis. I understand what that is but I’m confused after doing some research as to the difference between portal vein thrombosis and portal vein hypertension? Or
Lvbv
in
British Liver Trust
4 months ago
The role of JAK2V617F allele burden in PV
Conclusion « The knowledge of the JAK2V617F mutation in relation to PV has allowed both physicians and patients to understand that risk is not inherently based on blood counts alone but also due to the effects of JAK2V617F VAF on thrombosis and disease progression. Prospective trials are now highlighting
Conclusion « The knowledge of the JAK2V617F mutation in relation to PV has allowed both physicians and patients to understand that risk is not inherently based on blood counts alone but also due to the effects of JAK2V617F VAF on thrombosis and disease progression. Prospective trials are now highlighting
Manouche
in
MPN Voice
8 months ago
Necrosing spleen
Does anyone have any experience of having a spleen embolisation? If so, did their spleen carry on necrosis 5 months later? Has anyone had a drain for 5 months outputting necrosing puss? How long were they in hospital for? My bother has PV and portal vein thrombosis and was directed to have radical
Does anyone have any experience of having a spleen embolisation? If so, did their spleen carry on necrosis 5 months later? Has anyone had a drain for 5 months outputting necrosing puss? How long were they in hospital for? My bother has PV and portal vein thrombosis and was directed to have radical
DeKa
in
MPN Voice
10 months ago
Purpura on w&w?
Since diagnosis 3 years ago, while on W&W, I have had presume purpura spots come and go on my left arm, but today, after reaching in to tomato cages to capture the best and presumably scraping my arm, I have developed a whole big area of what I assume to be purpura, spread over about 3 inches and not
Since diagnosis 3 years ago, while on W&W, I have had presume purpura spots come and go on my left arm, but today, after reaching in to tomato cages to capture the best and presumably scraping my arm, I have developed a whole big area of what I assume to be purpura, spread over about 3 inches and not
Vlaminck
in
CLL Support
11 months ago
Spleen embolisation gone wrong
Hello, Does anyone have any experience of why anyone with Polycythemia Vera and Portal Vein Thrombosis, with a 22cm spleen would be offered a partial splenectomy, a spleen embolisation through the groin? Has anyone been through this? My 48 year old brother went through this on 3rd April 2023 and
Hello, Does anyone have any experience of why anyone with Polycythemia Vera and Portal Vein Thrombosis, with a 22cm spleen would be offered a partial splenectomy, a spleen embolisation through the groin? Has anyone been through this? My 48 year old brother went through this on 3rd April 2023 and
DeKa
in
MPN Voice
11 months ago
Septic Shock hair loss
Hi i’m a 19 year old girl who suffered septic shock at the end of March of this year. I luckily am thriving now in June but a few days ago I started losing a bit more hair than usual (exactly 2 months after i was released from ICU). I got on google and looked it up and now see that the sepsis has caused
Hi i’m a 19 year old girl who suffered septic shock at the end of March of this year. I luckily am thriving now in June but a few days ago I started losing a bit more hair than usual (exactly 2 months after i was released from ICU). I got on google and looked it up and now see that the sepsis has caused
cici2024
in
ICUsteps
10 days ago
Trelegy and pneumonia?
In April this year, I was prescribed Trelegy after an exacerbation that resulted in respiratory failure. I have read that people who are on Trelegy are a lot more likely to get pneumonia but I had the vaccination a couple of years ago so I am a little confused. Does anyone know anything about this?
In April this year, I was prescribed Trelegy after an exacerbation that resulted in respiratory failure. I have read that people who are on Trelegy are a lot more likely to get pneumonia but I had the vaccination a couple of years ago so I am a little confused. Does anyone know anything about this?
Coughingalltheway
in
Lung Conditions Community Forum
11 days ago
Tetanus
Not too far back there was a discussion about having a Tetanus shot, might help PD. I tried a search and came up with only one 2 year old post. No very Techy. Can someone help me find the link to that discussion? Thank you
Not too far back there was a discussion about having a Tetanus shot, might help PD. I tried a search and came up with only one 2 year old post. No very Techy. Can someone help me find the link to that discussion? Thank you
Ghmac
in
Cure Parkinson's
14 days ago
RA got worse after pneumonia
After pneumonia my ra took a turn for the worse. Could a medicine change help
After pneumonia my ra took a turn for the worse. Could a medicine change help
Vonnie69
in
NRAS
23 days ago
Azithromycin
Discharged recently from hospital after a long period of exacerbations and then pneumonia. After weeks of oral antibiotics and steroids had to have IV antibiotics. Next time I will probably have to begin IV immediately on flare up. I take 250 mg Azithromycin 3 times a week and was wondering does any
Discharged recently from hospital after a long period of exacerbations and then pneumonia. After weeks of oral antibiotics and steroids had to have IV antibiotics. Next time I will probably have to begin IV immediately on flare up. I take 250 mg Azithromycin 3 times a week and was wondering does any
kenta
in
Lung Conditions Community Forum
25 days ago
Sepsis - a timely reminder
[i]“The paramedics were reluctant to take me in,” he said. “They thought I should go and see my GP. I could have gone back to sleep. And I would have died I suppose. After a bit of remonstration they agreed [to take me]. No doubt at all Kati saved my life. If we had got there two hours later I would
[i]“The paramedics were reluctant to take me in,” he said. “They thought I should go and see my GP. I could have gone back to sleep. And I would have died I suppose. After a bit of remonstration they agreed [to take me]. No doubt at all Kati saved my life. If we had got there two hours later I would
bennevisplace
in
CLL Support
30 days ago
Tetanus Vaccine Decreases Incidence of Parkinson’s Disease and Slows Its Progression
Very interesting article: [u]
Tetanus Vaccine Decreases Incidence of Parkinson’s Disease and Slows Its Progression
[/u]
2024
https://www.gilmorehealth.com/tetanus-vaccine-decreases-incidence-of-parkinsons-disease-and-slows-its-progression/ It is based on this paper: [u]
Tetanus vaccination
Very interesting article: [u]
Tetanus Vaccine Decreases Incidence of Parkinson’s Disease and Slows Its Progression
[/u]
2024
https://www.gilmorehealth.com/tetanus-vaccine-decreases-incidence-of-parkinsons-disease-and-slows-its-progression/ It is based on this paper: [u]
Tetanus vaccination
Bolt_Upright
in
Cure Parkinson's
1 month ago
Infections like pneumonia and sinus. Lessons learned.
I’m saddened and sorry for all those who have been suffering from pneumonia and respiratory infections. Been posted of late. As a physician who knows better, I wish I’d followed my on advice to do ALL of the following 1. Test right away for COVID 2. Get a complete viral nasal swab to be tested
I’m saddened and sorry for all those who have been suffering from pneumonia and respiratory infections. Been posted of late. As a physician who knows better, I wish I’d followed my on advice to do ALL of the following 1. Test right away for COVID 2. Get a complete viral nasal swab to be tested
skipro
in
CLL Support
1 month ago
Recovery from pneumonia
70 YO F with bronchiectasis - I developed double pneumonia 3 months ago and completed 2 weeks of IV antibiotic treatment in hospital and at home 2 months ago. Is it normal for recovery from pneumonia to wax and wane, to be "nonlinear"? I was getting better 2 weeks ago, the fatigue was starting to lift
70 YO F with bronchiectasis - I developed double pneumonia 3 months ago and completed 2 weeks of IV antibiotic treatment in hospital and at home 2 months ago. Is it normal for recovery from pneumonia to wax and wane, to be "nonlinear"? I was getting better 2 weeks ago, the fatigue was starting to lift
eoram25
in
Lung Conditions Community Forum
2 months ago
nose bleed
was rushed to hospital 2weeks ago for pneumonia. Was discharged after a week. Wasn’t home 24 hrs. And out of the blue my nose started bleeding. It hasn’t stopped. Has this happened to anyone else and what did the doctors do to stop it?
was rushed to hospital 2weeks ago for pneumonia. Was discharged after a week. Wasn’t home 24 hrs. And out of the blue my nose started bleeding. It hasn’t stopped. Has this happened to anyone else and what did the doctors do to stop it?
Daytym
in
British Liver Trust
2 months ago
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