What could be causing weight gain when bloods a... - Thyroid UK

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What could be causing weight gain when bloods are optimum?

Tiredofthis77 profile image
14 Replies

Hi all,

I'd really like to get some advice re my results. I have been on a long journey (26 years) and never been able to tolerate thyroxine. After investigation it was discovered my reverse T3 was high and likely caused by me having the DIO2 variant.

About three years ago I went private and absolutely thrived on Erfa. The weight fell off without effort (about two stones) in a matter of months and everything was dandy.

Sadly though, about a year ago the weight started going back on, despite a healthy diet and daily exercise - I've never been so healthy in my life before) and I'm now two stones heavier again with the bulk of the weight on my tummy and top of thighs). Bloods look optimal and doc is puzzled. He tried me on metformin two weeks ago thinking it might be insulin resistance and the weight is continuing to go on and I feel very hypo. Can I please get your thoughts? I thought I had a breakthrough and now I feel worse than ever.

Thanks for listening.

Tired

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Tiredofthis77 profile image
Tiredofthis77

FT4 in range

FT4 results 19.2 (range 12-22)
Tiredofthis77 profile image
Tiredofthis77 in reply to Tiredofthis77

FT3 in range

FT3 in range
Tiredofthis77 profile image
Tiredofthis77 in reply to Tiredofthis77

Vitamin D

Vitamin D
Tiredofthis77 profile image
Tiredofthis77

Glycated haemoglobin

Glycated haemoglobin
Tiredofthis77 profile image
Tiredofthis77

B12

B12
Tiredofthis77 profile image
Tiredofthis77 in reply to Tiredofthis77

Folate

Folate
LucyYoga profile image
LucyYoga

Hi-

I would look into leptin resistance and cortisol levels. Both can cause weight gain especially around the middle.

Many people with hypothyroidism who still struggle with excess weight despite being optimally medicated have leptin resistance as a root cause.

Tiredofthis77 profile image
Tiredofthis77 in reply to LucyYoga

Thank you. Do you know where I can get tested for this?

pennyannie profile image
pennyannie

Hello Tiredofallthis :

Do you have Free T3 and Free T4 readings and ranges please - what time lapse was there between last dose and the fasting blood draw and are you still taking Efra - how much - and do you split your dose or take it all at once ?

Did you manage to get tested 5 months ago as suggested for IGF-1 - insulin and cortisol ?

Tiredofthis77 profile image
Tiredofthis77 in reply to pennyannie

Thank you for responding. I posted the Free T3 and Free T4 in replies as they wouldn't attach to my original message. I took the last dose of Erfa at noon the previous day and was tested at 9am the next day. Erfa dose is 2 grains at 7am and 1 and a half at noon.

Cortisol was 266. No range given

Insulin Like GF-1 was 122.2 (range 56.8-194.5)

Thanks for your help

results
pennyannie profile image
pennyannie in reply to Tiredofthis77

This results show different and more realistic blood test results when taking NDT -

as when on NDT we track on the T3 and your T3 is around 72% and proportionately higher in its range than T4 which I've got coming in at around 22% -

were you feeling better whenever this blood test was run as I can't see a date ?

We generally recommend taking a blood draw around 12 hours after taking NDT so these other results show a false low -

which appear to be a T3 of 6.60 ( 3.10-6.80 ) and a T4 at 19.20 ( 12 - 22.00 )

I'm sorry but I've no knowledge of the cortisol reading nor the IGF - ( was hoping to learn something and why I asked the question ) and fully understand - being in a range - doesn't mean as much as optimal and feeling well.

Regenallotment profile image
Regenallotment

How is your ferritin? I find my weight is linked to ferritin and absorption of the hormone circulating. 🌱

Tiredofthis77 profile image
Tiredofthis77 in reply to Regenallotment

This is my latest result

Ferritin
Regenallotment profile image
Regenallotment in reply to Tiredofthis77

Not that then…

Are you exercising a lot?

as in too much with hypothyroidism leaves you metabolically challenged…

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